منابع مشابه
SNPing away at sickle cell pathophysiology.
was well tolerated in phase 1 and 2 studies, and therefore has already passed its first important test. Nevertheless, inhibition of JAK2 raises concerns, since JAK2 is required for signaling by the receptors for erythropoietin, thrombopoietin, and in part, G-CSF. In this respect, it is encouraging that cells carrying JAK2-V617F were more sensitive to the inhibition of lestaurtinib than cells wi...
متن کاملSlugging It out: Fine Tuning the p53-PUMA Death Connection
In response to DNA damage, the tumor suppressor p53 elicits a complex cellular response. In this issue of Cell, Wu et al. (2005) show that the transcription factor SLUG is induced by p53 and protects hematopoietic progenitor cells from apoptosis triggered by DNA damage. SLUG exerts this protective role by repressing Puma, a proapoptotic target of p53. PUMA is also a key coordinator of apoptosis...
متن کاملSquirreling away at Parkinson's.
A compound that triggers hibernation in ground squirrels can also protect brain cells from the lack of oxygen following a stroke.
متن کاملChipping away at the Embryonic Stem Cell Network
Critical transcription factors, notably OCT4, SOX2, and NANOG, are necessary to maintain self-renewal and pluripotency, two properties characteristic of embryonic stem (ES) cells. By analyzing the genome-wide localization of these factors at promoter regions in human ES cells, Boyer et al. (2005) demonstrate frequent promoter co-occupancy at numerous target genes. As they discuss in this issue ...
متن کاملSNPing away at candidate genes.
We develop regression methodology to identify subsets of single nucleotide polymorphisms (SNPs) within candidate genes related to quantitative traits and apply our methods to the simulated Genetic Analysis Workshop (GAW) 12 data set. In the data set we find 694 SNP loci with minimum allele frequencies of at least 0.01. We assume an additive casual model between these SNPs and all five quantitat...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2002
ISSN: 1535-6108
DOI: 10.1016/s1535-6108(02)00156-3